Experiment Updates Eötvös & The Dynamics of Jetlag →
Open Source

The Copernican Toolkit

Free, open-source tools for scientists who take Earth's motion seriously.
Compute, visualize, and export the hidden dynamics of any location on Earth.

View on GitHub Try the Calculator ↓

What Is This?

As stated in our Mission statement - our goal is to bring a new paradigm to biology by finishing the Copernican revolution. Every mass on Earth is embedded in a complex, periodic acceleration field driven by our planet's spin, lunar gravity, and solar orbit. These motions produce real, calculable strain cycles — jerk, snap, and higher-order dynamics that oscillate with diurnal, lunar, and annual periodicities.

CHECK OUT OUR FIRST TOOL: The Earth Frame Calculator — it makes these invisible dynamics visible! Enter any location on Earth and instantly see the velocity fields, accelerations, and strain periodicities that every molecule at that location experiences — dynamic factors acting on cells that has traditionally been ignored.

Interactive Tool

Earth Frame Calculator

Enter a location to compute its dynamical environment.

Available Now

Tools & Integrations

🐍

Python Library

Install with pip install copernican-toolkit and compute Earth-bound dynamics in 3 lines of code. Includes Jupyter notebooks, visualization tools, and full API documentation.

GitHub →
📊

R Package

Native R package for the biostatistics community. Compute frame dynamics and export data directly into your R analysis pipeline. Compatible with tidyverse workflows.

GitHub →
🤖

MCP Server

Use earthframe from any AI assistant (Claude, ChatGPT, Cursor) via the Model Context Protocol. Ask questions in natural language and get computed dynamics back instantly.

GitHub →
Example Analysis

What the ISS Mice Lost

We applied the Copernican Toolkit to real spaceflight biology data from NASA GeneLab (OSD-242) — mouse liver transcriptomics from the SpaceX-12 mission (33 days on the ISS).

The ground control mice at Kennedy Space Center experienced rich, periodic acceleration dynamics — with dominant strain cycles at ~12 hours driven by lunar tidal forces. The ISS mice lost these dynamics entirely.

The result: 321 genes were significantly differentially expressed — 257 downregulated in flight. The disrupted pathways include circadian clock genes (Nr1d1, Nr1d2, Npas2, Rorc), oxidative stress response, lipid and glucose metabolism, and immune function.

These are exactly the pathways that would be modulated by the 12-hour and 24-hour strain periodicities our toolkit quantifies. The ISS mice didn't just lose "gravity" — they lost the periodic dynamics embedded in Earth's reference frame.

Earth-bound frame dynamics at Kennedy Space Center during SpaceX-12 mission

Earth-Bound Frame Dynamics at Kennedy Space Center

7 days of tidal acceleration, jerk, and strain rate at the ground control location during the SpaceX-12 mission. The ~12-hour periodicity in the tidal acceleration is clearly visible — a rhythm the ISS mice never experienced.

Volcano plot of differentially expressed genes - ISS flight vs ground control

Gene Expression: Flight vs Ground

321 significantly differentially expressed genes. Gold = upregulated in flight, blue = downregulated. The asymmetry (257 down, 64 up) suggests broad transcriptional suppression in microgravity.

Strain cycle frequency spectrum at Kennedy Space Center

Strain Cycle Spectrum

FFT decomposition of the acceleration time series at KSC over 34 days. The dominant peak at ~12 hours is the semi-diurnal tidal cycle — a candidate timing signal for metabolic gene regulation.

Disrupted Pathways in Spaceflight

Pathway Key Genes Direction
Circadian Clock Nr1d1, Nr1d2, Npas2, Rorc ↑↓ Mixed
Oxidative Stress Nqo1 ↑↑↑, Gstp1, Gstm4, Gsta3 Reshuffled
Glucose Metabolism Pck1 (gluconeogenesis), Pfkl (glycolysis) ↑ Upregulated
Lipid Metabolism Ppargc1a, Srebf2 ↑ Upregulated
Immune Response Il1b ↓↓, Cxcl9 ↓↓↓ ↓ Suppressed

Full analysis script and data available in the GitHub repository. Data source: NASA OSDR OSD-242 (open access).

Roadmap

What's Coming Next

Module Description Status
earthframe Earth-bound reference frame dynamics ✓ Released
periodicity Detect circadian, circalunar, and annual cycles in biological data In Development
isomerdb Nuclear isomeric states database at biological energies Planned
isotope-tools Heavy isotope fractionation analysis for metabolic studies Planned
spacebio Biological data analysis for altered-gravity environments Planned